According to McCarty, when combined with garcinia, L-carntine may be even more effective at assisting fat metabolism. The oxidation (metabolism) of fats is determined by an enzyme in the liver known as carnitine acyltransferase. It has been shown that the activity of this enzyme is activated by dietary carnitine (as in supplemental L-carnitine), but inhibited by another enzyme malonyl co-enzyme A.

 

HCA from garcinia, not only inhibits the fat-producing enzyme ATP-citrate lyase, but also decreases the production of malonyl co-enzyme A. So it supports the efficacy of L-carnitine by protecting it from the inhibiting enzyme.